CBN May Help Prevent Alzheimer’s and Other Neurodegenerative Diseases, Such as Parkinson’s
Active ingredient in cannabis protects aging brain cells
Healthy mitochondria (green); mitochondria showing the effects of oxidative stress (blue); and oxidative stress with CBN (red). Insets show higher magnification of the structure of the mitochondria.
Credit: Salk Institute
Salk researchers find cannabinol preserves mitochondrial function and prevents oxidative damage to cells
LA JOLLA—Decades of research on medical cannabis has focused on the compounds THC and CBD in clinical applications. But less is known about the therapeutic properties of cannabinol (CBN). Now, a new study by Salk scientists shows how CBN can protect nerve cells from oxidative damage, a major pathway to cell death. The findings, published online January 6, 2022, in the journal Free Radical Biology and Medicine, suggest CBN has the potential for treating age-related neurodegenerative diseases, like Alzheimer’s.
“We’ve found that cannabinol protects neurons from oxidative stress and cell death, two of the major contributors to Alzheimer’s,” says senior author Pamela Maher, a research professor and head of Salk’s Cellular Neurobiology Laboratory. “This discovery could one day lead to the development of new therapeutics for treating this disease and other neurodegenerative disorders, like Parkinson’s disease.”
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